USP7-IN-1_DataSheet_MedChemExpress

Inhibitors, Agonists, Screening Libraries

https://www.sodocs.net/doc/fa3313363.html, Data Sheet

BIOLOGICAL ACTIVITY:

USP7–IN–1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM; less or no inhibition on USP5, USP8, Uch–L1,Uch–L3 and Caspase(IC50>200 uM); HCT116 cell viability GI50 is 67 uM.

IC50 value: 33 uM

Target: USP7 selective inhibitor

Preparation of quinazoline derivatives useful as selective and reversible inhibitors of USP7

By Colland, Frederic; Gourdel, Marie–Edith

From PCT Int. Appl. (2013), WO 2013030218 A1 20130307.

Product Name:

USP7–IN–1Cat. No.:

HY-16709CAS No.:

1381291-36-6Molecular Formula:

C 23H 24ClN 3O 3Molecular Weight:

425.91Target:

Deubiquitinase Pathway:

Cell Cycle/DNA Damage Solubility:

DMSO: ≥ 40 mg/mL

Caution: Product has not been fully validated for medical applications. For research use only.

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https://www.sodocs.net/doc/fa3313363.html,