AZD1152-HQPA_722544-51-6_DataSheet_MedChemExpress

Product Name:

AZD1152-HQPA CAS No.:

722544-51-6

Product Data Sheet

Cat. No.:

HY-10126MWt:

507.56Formula:

C26H30FN7O3Purity :

>98%

Solubility:Mechanisms:

Biological Activity:

Pathways:Cell Cycle/DNA Damage; Target:Aurora Kinase DMSO ≥100mg/mL Water ≥

100mg/mL Ethanol ≥2.8mg/mL

g y AZD1152-HQPA(Barasertib) is a highly potent and selective Aurora B inhibitor with a Ki of 0.36 nM.References:

[1]. Oke, Adedayo; Pearce, Daniel; Wilkinson, Robert W.; AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo. Cancer

Research (2009), 69(10), 4150-4158.[2]. Yang, Jing; Ikezoe, Takayuki; Nishioka, Chie; Tasaka, Taizo; Taniguchi, Ayuko; AZD1152, a []g g y g y

novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and

in vivo. Blood (2007), 110(6), 2034-2040.[3]. Grundy M, Seedhouse C, Shang S, Richardson J, Russell N, Pallis M.The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute

myelogenous leukemia cells.Mol Cancer Ther. 2010 Mar;9(3):661-72. Epub 2010 Feb 16.[4]. Walsb...

Caution: Not fully tested. For research purposes only

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