HY-P0232_25018_MCE
Data Sheet
BIOLOGICAL ACTIVITY:
Fmoc–Thr[GalNAc(Ac)3–α–D]–OH is a building block in the development of cancer vaccines.
In Vitro: The O–glycosidic linkage and the O–acetyl protection in this building block is stable to both piperidine and TFA, making it
completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor–associated
carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O–glycosylation pathway in which glycans are extended from the common precursor GalNAcα1–O–Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α– N–acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O–glycan Galβ1–3GalNAcα1–OSer/Thr (T antigen) by a single enzyme termed the T–synthase (core 1β3–galactosyltransferase or C1GalT). Formation of the active form of the T–synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X–chromosome [1].
References:
[1]. Ju T, et al. The Cosmc connection to the Tn antigen in cancer. Cancer Biomark. 2014 Jan 1;14(1):63-81.
Product Name:Fmoc–Thr[GalNAc(Ac)3–α–D]–OH Cat. No.:HY-P0232CAS No.:
116783-35-8Molecular Formula:C 33H 38N 2O 13Molecular Weight:670.66Target:Others Pathway:Others Solubility:
DMSO
Caution: Product has not been fully validated for medical applications. For research use only.
Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@https://www.sodocs.net/doc/5d10868965.html,
Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
Certificate of Analysis
PHYSICAL AND CHEMICAL PROPERTIES
Molecular Formula:C 33H 38N 2O 13Molecular Weight:670.66Storage:
Powder -20°C 3 years 4°C 2 years In solvent
-80°C 6 months -20°C
1 month
Chemical Structure:
ANALYTICAL DATA
Appearance:White to off-white (Solid)HPLC:Consistent with structure Purity (HPLC):97.72%
Conclusion:
The product has been tested and complies with the given specifications.
Product Name:Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Cat. No.:HY-P0232CAS No.:116783-35-8Batch No.:25018
Chemical Name:
L-Threonine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-α-D-galactopyranosyl]-
Caution: Product has not been fully validated for medical applications. For research use only.
Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@https://www.sodocs.net/doc/5d10868965.html,
Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
Safety Data Sheet Revision Date:Jun.-22-2017
Print Date:Jun.-22-2017
1. PRODUCT AND COMPANY IDENTIFICATION
1.1 Product identifier
Product name :Fmoc-Thr[GalNAc(Ac)3-α-D]-OH
Catalog No. :HY-P0232
CAS No. :116783-35-8
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses :Laboratory chemicals, manufacture of substances.
1.3 Details of the supplier of the safety data sheet
Company:MedChemExpress USA
Tel:609-228-6898
Fax:609-228-5909
E-mail:sales@https://www.sodocs.net/doc/5d10868965.html,
1.4 Emergency telephone number
Emergency Phone #:609-228-6898
2. HAZARDS IDENTIFICATION
2.1 Classification of the substance or mixture
Not a hazardous substance or mixture.
2.2 GHS Label elements, including precautionary statements
Not a hazardous substance or mixture.
2.3 Other hazards
None.
3. COMPOSITION/INFORMATION ON INGREDIENTS
3.1 Substances
Synonyms:None
Formula:C33H38N2O13
Molecular Weight:670.66
CAS No. :116783-35-8
4. FIRST AID MEASURES
4.1 Description of first aid measures
Eye contact
Remove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.
Skin contact
Rinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.
Inhalation
Immediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.
Ingestion
Wash out mouth with water; Do NOT induce vomiting; call a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2).
4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically.
5. FIRE FIGHTING MEASURES
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, dry chemical, foam, and carbon dioxide fire extinguisher.
5.2 Special hazards arising from the substance or mixture
During combustion, may emit irritant fumes.
5.3 Advice for firefighters
Wear self-contained breathing apparatus and protective clothing.
6. ACCIDENTAL RELEASE MEASURES
6.1 Personal precautions, protective equipment and emergency procedures
Use full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.
Refer to protective measures listed in sections 8.
6.2 Environmental precautions
Try to prevent further leakage or spillage. Keep the product away from drains or water courses.
6.3 Methods and materials for containment and cleaning up
Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.
7. HANDLING AND STORAGE
7.1 Precautions for safe handling
Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
7.2 Conditions for safe storage, including any incompatibilities
Keep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.
Recommended storage temperature:Powder-20°C 3 years
4°C 2 years
In solvent-80°C 6 months
-20°C 1 month
Shipping at room temperature if less than 2 weeks.
7.3 Specific end use(s)
No data available.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1 Control parameters
Components with workplace control parameters
This product contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering controls
Ensure adequate ventilation. Provide accessible safety shower and eye wash station.
Personal protective equipment
Eye protection Safety goggles with side-shields.
Hand protection Protective gloves.
Skin and body protection Impervious clothing.
Respiratory protection Suitable respirator.
Environmental exposure controls Keep the product away from drains, water courses or the soil. Clean
spillages in a safe way as soon as possible.
9. PHYSICAL AND CHEMICAL PROPERTIES
9.1 Information on basic physical and chemical properties
Appearance White to off-white (Solid)
Odor No data available
Odor threshold No data available
pH No data available
Melting/freezing point No data available
Boiling point/range No data available
Flash point No data available
Evaporation rate No data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limits No data available
Vapor pressure No data available
Vapor density No data available
Relative density No data available
Water Solubility No data available
Partition coefficient No data available
Auto-ignition temperature No data available
Decomposition temperature No data available
Viscosity No data available
Explosive properties No data available
Oxidizing properties No data available
9.2 Other safety information
No data available.
10. STABILITY AND REACTIVITY
10.1 Reactivity
No data available.
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available.
10.4 Conditions to avoid
No data available.
10.5 Incompatible materials
Strong acids/alkalis, strong oxidising/reducing agents.
10.6 Hazardous decomposition products
Under fire conditions, may decompose and emit toxic fumes.
Other decomposition products - no data available.
11.TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects
Acute toxicity
Classified based on available data. For more details, see section 2
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
IARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.
NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.
OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
12. ECOLOGICAL INFORMATION
12.1 Toxicity
No data available.
12.2 Persistence and degradability
No data available.
12.3 Bioaccumlative potential
No data available.
12.4 Mobility in soil
No data available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.
12.6 Other adverse effects
No data available.
13. DISPOSAL CONSIDERATIONS
13.1 Waste treatment methods
Product
Dispose substance in accordance with prevailing country, federal, state and local regulations.
Contaminated packaging
Conduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.
14. TRANSPORT INFORMATION
DOT (US)
This substance is considered to be non-hazardous for transport.
IMDG
This substance is considered to be non-hazardous for transport.
IATA
This substance is considered to be non-hazardous for transport.
15. REGULATORY INFORMATION
SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
No SARA Hazards.
Massachusetts Right To Know Components:
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components:
No components are subject to the Pennsylvania Right to Know Act.
New Jersey Right To Know Components:
No components are subject to the New Jersey Right to Know Act.
California Prop. 65 Components:
This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.
16. OTHER INFORMATION
Copyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.
Caution: Product has not been fully validated for medical applications. For research use only.
Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@https://www.sodocs.net/doc/5d10868965.html,
Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
Catalog No : HY-P0232 Batch#25018